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BMI body mass index ATP adenosine triphosphate ROS reactive oxygen species 2,3-BPG 2,3-Bisphosphoglycerate 1,3-BPG 1,3-Bisphosphoglycerate 3-BPG 3-Bisphosphoglycerate TCA tricarboxylic acid PGI2 prostacyclin TXA2 thromboxin PUFAs polyunsaturated fatty acids SCAD short-chain acyl-coenzyme A dehydrogenase LCPUFAs long-chain polyunsaturated fatty acids DHA docosahexaenoic acid AA arachidonic acid LCHAD long chain omega-3 hydroxy CoA dehydrogenase GSH glutathione Trp tryptophan Arg arginine Hcy homocysteine GSSG glutathione oxidized GPx glutathione peroxidase CAT catalase GSTT2 Glutathione S-transferase theta 2 KYN kynurenine TPH tryptophan hydroxylase IDO indolamine 2,3-dioxygenase TDO tryptophan2,3-dioxygenase GCN2 general control non-derepressible 2 eIF-2 eukaryotic translation initiation factor-2 GLK1 master amino acid-sensing kinase 1 AhR aromatic hydrocarbon receptor MAO monoamine oxidase 5-HIAA 5-hydroxyindole acetic acid NO nitric oxide NOS nitric oxide synthase GUC guanylate cyclase cGMP guanosine cyclomonophosphate ADMA asymmetric dimethylarginine DDAH dimethylarginine dimethylamine hydrolase MHM methionine-homocysteine metabolism MET methionine MTR methyltransferase 5-MTHF 5-methyltetrahydrofolate MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase MTHFR 5,10-methylenetetrahydrofolate reductase THF tetrahydrogen folic acid SAM S-adenosylhomocysteine CBS cystathionine synthase Cys cysteine 2-ME 2-methoxyestradiol COMT Catechol-O-methyltransferase 2-HE 2-Hydroxyestradiol sPE severe preeclampsia MMP-2/9 matrix metalloproteinase-2/9 MET metformin HMGCR 3-hydroxy-3-methylglutarate monoacyl-CoA reductase EGCG epigallocatechin gallate Glossary References 1

Methods Animals C57Bl6/J male and female mice were acquired from the National Institute on Aging mouse colony and housed at the University of Washington in a specific-pathogen free facility

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