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These infections not only diminish quality of life but also impose a substantial socio-economic burden, with billions of dollars spent annually on treatment and disability support

Given that core metabolic processes, including nucleotide synthesis, glycolysis, and redox defense, are fundamentally shared with normal proliferative tissues, broad-spectrum metabolic inhibition often lacks true selectivity and precipitates dose-limiting systemic toxicities [43]

This will hopefully prove particularly useful in the analysis of circulating steroids, making it possible to rigorously evaluate the role of CYP-mediated estrogen metabolism Citation[24] and facilitate the development of new models of breast cancer risk Citation[25]