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Description

Stimulation by LPS and A induces microglial polarization towards the M1 phenotype, which involves significant reprogramming of glucose metabolism from OXPHOS to glycolysis, which is dependent on the mTOR-HIF-1 pathway

30 March 2006

About 20% of people 65 and older have untreated tooth decay, and approximately half of US adults aged 30 and older have periodontitis (AAP 2015

Accordingly, the present invention provides methods of generating monoclonal antibodies as well as antibodies produced by the method comprising culturing a hybridoma cell secreting an antibody of the invention wherein, preferably, the hybridoma is generated by fusing splenocytes isolated from a mouse immunized with an antigen of the invention with myeloma cells and then screening the hybridomas resulting from the fusion for hybridoma clones that secrete an antibody able to bind a polypeptide of the invention