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By blocking NNMT, 5-amino1MQ stimulates an increase in nicotinamide adenine dinucleotide (NAD+), a cofactor that is at the root of cellular metabolism, thereby increasing metabolic rate and activating the sirtuin-1 gene which has also been called the longevity gene. And if youre wondering what cellular energy is, it serves as the very foundation for helping you feel energetic and alive: Our bodies contain trillions of cells