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Gastrointestinal effects: the main titration bottleneck Nausea, diarrhea, constipation, and vomiting run around 40 to 44% overall, dose-dependent in how many people report them but mild-dominant in severity: severe events stay at or below about 1.7% in any category even at the top dose. In the obesity program the by-dose rates run nausea 25/29/28%, diarrhea 19/21/23%, and vomiting 8/11/13% at 5/10/15 mg. They concentrate during escalation and ease with time on a held dose

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Other Causes of Diarrhoea When Taking B12 When diarrhoea develops after starting B12 supplementation, it is essential to consider alternative explanations that may coincide with, rather than result from, the vitamin therapy

10.1021/jacsau.5c00625 696 WhitmoreL.WallaceB