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H.MoonY.HanS

They regulate key biological processes such as inflammation, cellular migration, proliferation, and angiogenesis [19, 20]

This process activates oncogenes or inhibits tumor suppressor genes, thereby promoting tumor formation and development

In particular, carrier family 38 member 1 (SLC38A1)- and SLC1A5-mediated l-glutamine (but not d-glutamine) uptake and subsequent glutaminase 2 (GLS2, but not GLS1)-mediated glutamate production is required for cystine deprivation- or erastin-induced ferroptosis 40 (Fig