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A randomised, double-blind, placebo-controlled trial of Bifidobacterium bifidum CCFM16 for manipulation of the gut microbiota and relief from chronic constipation

They are characterized by extreme spatiotemporal heterogeneity, as instead of possessing a single unique structure, they exist as dynamic, interconverting ensembles of multiple conformations

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Doxorubicin treatment led to striking reductions in proteins involved in ceramide biosynthesis, including ceramide synthase 5 (Cers5) and ceramide transporter 1 (Cert1), which were rescued by NMN co-treatment (Fig