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Research demonstrates that these metabolic effects are accompanied by improvements in insulin sensitivity markers including reduced fasting insulin levels, improved glucose tolerance, and enhanced insulin-stimulated glucose disposal rates in peripheral tissues

Besides, as the realization of ferroptosis is usually achieved through lipid peroxidation accumulation and cell membrane damage, it remains to be determined whether lipid peroxides will damage normal cells and whether there will be other potential side effects caused by ferroptosis

Despite the encouraging effects of pre-clinical examines, a translational gap exists between fundamental invention and clinical application [58]

Ann Neurol 58:963967 Chen WW, Zhang X, Huang WJ (2016) Role of neuroinflammation in neurodegenerative diseases (Review)