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Interestingly, in adults, supplementation with vitamin B 12 early enough can delay the onset of depression and improve the effect of antidepressant drugs when used as adjunctive therapy [40]

(2020) found that XCHD significantly inhibits the upregulation of Hsp47, TGF-1, Col1A1, -SMA, etc., mediating the HSP47/TGF- axis to protect the liver

The evidence presented highlights how chronic ethanol consumption contributes to the onset of depressive disorders through various pathways, including the escalation of oxidative stress, the promotion of neuroinflammation, and the dysregulation of neurotrophic factors