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Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers

Research shows that slu pp works through REV-ERB receptor modulation, giving researchers tools to study circadian metabolism, mitochondrial function and exercise-mimetic cellular responses

Additional investigations may be requested when results are equivocal or to establish the underlying cause: Holotranscobalamin (active B12) : Available in some UK laboratories and may be more sensitive for detecting early deficiency