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Additional experiments have observed heightened levels of GSH and a higher GSH/GS-SG ratio in the bloodstream of melanoma cells, suggesting a more oxidative blood environment that could potentially promote ferroptosis

10.1016/j.biopha.2021.112005 114 XiaoR.WangS.GuoJ.LiuS.DingA.WangG.et al (2022)

This provides a route for microbial byproducts to influence brain activity in real time

Medicinal Chemistry is a scientific discipline involved with designing, synthesizing and developing pharmaceuticals suitable for therapeutic use Highly interdisciplinary science combining genetics, molecular biology, biochemistry, organic chemistry, pharmacology, toxicology Outline Background Drug Metabolism Pharmacogenetics Examples CYP2D6 Codeine DDI Scenario (fluoxetine) ALDH2 Ethanol DDI Scenario (acetaminophen) Basic Vocabulary Lipophilicity vs Hydrophilicity Lipophile: Fat-lover Hydrophile: Water-lover Xenobiotic: a foreign chemical substance More Basic Vocabulary Metabolism: chemical reactions that occur in living organisms Enzyme: a biomolecule that catalyzes a chemical reaction Inducer Enzyme Xenobiotic Metabolite Inhibitor Todays Focus We will focus on the enzymatic conversion of lipophilic xenobiotics to more water soluble metabolites