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(30) constructed a model of hypocalcemic cataract in rabbits by feeding a low-calcium diet and divided the hypocalcemic cataracts into three stages, including posterior subcapsule punctate opacity, dense opacity, and extension to the superficial anterior cortical layer, and suggested that aqueous humor calcium can be inferred from the serum calcium

To address the limitations of current drug testing strategies mainly involving 2D cell cultures and animal testing, a three-dimensional microphysiological model of the human liver containing expandable human liver sinusoidal endothelial cells, monocyte-derived macrophages and differentiated HepaRG cells was utilized to investigate the toxicity of trovafloxacin and compared it to the structurally-related non-toxic drug levofloxacin