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[DOI] [PubMed] [Google Scholar] 31.Fredrikson G, Tornqvist H, Belfrage P

Folate metabolism can be impaired by 2 different polymorphisms of MTHFR: MTHFR 677CT + MTHFR 1298AC = lowest MTHFR activity MTHFR 677C/T is associated with a significant decrease of MTHFR enzymatic activity that can reach up to 70% in homozygous (MTHFR T/T), while the heterozygous (C/T) genotype has a 35% decreased activity