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This herb should never be used during pregnancy, as it has been associated with dangerous side effects like high blood pressure, heart attacks, and seizures

The underlying mechanism is to promote the activation of NLRP3 inflammasome by activating TLR4/MyD88/NF-kB signaling pathway, resulting in the up-regulation of downstream caspase-1 expression and the increase of IL-1 release, and ultimately inducing pyroptosis of intestinal cells ( Curcumin attenuates NLRP3/caspase-1-induced pyroptosis by activating the SIRT1/NRF2 signaling pathway or inhibiting TLR4 expression, thereby reducing intestinal injury in the rat model of NEC ( Bacteroides fragilis strain ZY-312 ( Cronobacter sakazakii -induced pyroptosis by inhibiting caspase-1 and decreasing IL-1 in NEC rats

Intriguingly, the proinflammatory cytokine IL-23 has been identified as a stimulant for CDK7 expression in CD4+ T cells, further amplifying glycolytic activity through activation of the PKB/mTOR/HIF-1 signaling network in a psoriasis-like mouse model induced by imiquimod (IMQ) (19)

Furthermore, chest computed tomography images of the Cohort 2 LC group showed significant lung lesion improvement, suggesting that LC may slow COVID-19 progression