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[7] [10] [11] Conversion of tamoxifen by N -demethylation into N -desmethyltamoxifen, which is catalyzed primarily by CYP3A4 and CYP3A5, is responsible for approximately 92% of tamoxifen metabolism

In patients with circulatory assist devices that produce non-pulsatile flow such as left ventricular assist devices (LVADs), the only indirect means of measuring flow requires use of a doppler