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Dysbiosis promotes a shift in TRP metabolism away from 5-HT and toward KYN, QA, and 3-HK, while simultaneously impairing intestinal barrier integrity and driving low-grade systemic inflammation, exaggerated cortisol reactivity, HPA-axis dysregulation, visceral adiposity, and cardiometabolic risk all features commonly comorbid with depression [178,179,180,181,182]

Mitochondrial Protection : Glutathione concentrates in mitochondria where it supports respiratory chain complexes, promoting efficient ATP production and supporting healthy mitochondrial function

PubMed Vitale SG, Corrado F, Caruso S, et al

Therefore, the antimicrobial effects of antidepressants should be rationally considered, while the importance of monitoring the profiles of microbes and ARGs in patients with depression should not be underestimated