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Keywords: Glycine deficiency, Glycine conjugation detoxification pathway, Severe obesity, Glutathione, 1-Carbon cycle, Dietary glycine supplementation Subject terms: Endocrine system and metabolic diseases, Nutrition, Non-alcoholic fatty liver disease Introduction Glycine is the simplest amino acid in the human body but is central to human metabolism and is required in large amounts to maintain normal health

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Together, these perspectives indicate that future AMS research should prioritize well-powered, mechanistically informed randomized trials, integration of redox and inflammatory biomarkers, and the exploration of multi-target antioxidant strategies that better reflect the complex pathophysiology of altitude illness

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