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Studies also demonstrated no significant inference of MTHFR C677T polymorphism in global DNA methylation in oral epithelial cell samples 31 or lymphocytes of healthy individuals 32 , as well as cutaneous squamous cell carcinoma in renal transplant patients 33

To elaborate, GSH co-localizes to the nucleus in proliferative events, which indicates that, via redox changes, it can affect the activity of many nuclear proteins, especially histones