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Used across pernicious anaemia, malabsorption, and many non-dietary causes

Although the current diagnosis would indicate people affected with PANS/PANDAS are children, adults have also been given this diagnosis, sometimes due to persistent symptoms following developing the condition as a child and other times due to developing the symptoms in adulthood

10.1021/acs.jafc.4c07890 J

Pericytes, contractile mural cells regulating capillary tone, exhibit HIF-1-mediated RhoA (Ras homolog gene family, member A)/Rho-associated protein kinase (ROCK) pathway activation, leading to sustained contraction and capillary no-reflow post-recanalization [122]