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The screening strategies included Scree-all, Risk-based screening, and No screening strategies followed by treatment

Similarly, 18 F-DOPA PET-guided, dose-escalated, hypofractionated proton beam therapy has shown potential survival benefits with manageable adverse effects, 343 warranting further investigation in phase 2 trials (NCT05781321)

van Ulsen et al., 2008

The absence of CRY has been hypothesized to release its inhibition on cAMP production, thereby increasing cAMP levels and PKA activation and, subsequently, PKA-mediated phosphorylation of the p65 subunit of NF-B, leading to its constitutive activation