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Supports skin repair and regeneration : Collagen contributes to skin repair and regeneration

233 , 234 Lastly, it is not known whether the use of biologics to successfully control chronic inflammatory responses might also diminish the senescence march in the long term

Chronic inflammation, driven by immune cell infiltration (macrophages, T cells, B cells) and pro-inflammatory cytokines (IL-1, TNF-, IL-6), activates signaling pathways such as NF-B and MAPK, promoting disc cell apoptosis and extracellular matrix (ECM) degradation (Figure 1)