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First, mechanistic studies should combine single-cell spatial transcriptomics with mitochondrial metabolomics to map ferroptosis pathways in spinal ventral horn motor neurons, microglia, and astrocytes, with emphasis on the coupling between NCOA4-mediated ferritinophagy and SOD1/TDP-43 clearance, thereby establishing a dynamic model linking mitochondrial iron dysregulation, proteotoxic stress, and cell death

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RNA modifications N6-methyladenosine (m 6 A) In RNA molecules, m 6 A, a crucial epigenetic modification, involves the addition of a methyl group to the nitrogen atom at the sixth position of adenosine

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