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Maeng HJ, Kim ES, Chough C, Joung M, Lim JW, Shim CK, et al

Metformin, as a ROS inhibitor, can maintain T cell activity by reducing intracellular ROS levels, thereby promoting tumor clearance and reducing tumor-associated inflammation [95]

The absence of mucin, a highly glycosylated polymeric protein in the mucous layer, makes an animal vulnerable to intestinal inflammation, which leads to the development of spontaneous colitis and confers a predisposition to the development of colorectal cancers (Fig