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Remarkably, each stage of the evolutionary process that gave rise to GS-like effectors has witnessed at least a 10-fold reduction in apparent glutathione synthetic rate, such that Clade 3 GS-like proteins have not retained canonical enzyme activity (Fig 3 and S2 Table)

14 BianM.LiuJ.HongX.YuM.HuangY.ShengZ.et al (2012)

Metabolic Pathway Observation Gene Regulatory Response Sirtuin-Associated Signaling Researchers evaluate MOTS-c for peptide signaling dynamics related to metabolic adaptation, cellular stress signaling, and receptor interaction activity in preclinical research

These three-dimensional, hydrophilic polymer networks could swell up in aqueous environments