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No mitochondrial pathology Brain MRI: Cerebellar atrophy MTATP6 variant syndrome: CNS & Motor 185 Epidemiology: 2 patients, 1 family Genetics Mutation: Homoplasmic T9185C Allelic disorders Clinical Onset age: 2nd or 3rd decade Cognitive impairment Exercise intolerance Motor: Weakness, proximal

This is interesting particularly from the perspective of the traditional androgen hypothesis as a cause of acne because it totally goes against what weve come to accept as the main contributing factor in acne development

12/15-lipoxygenase inhibition reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice

In smokers, there is a decrease in blood ascorbic acid levels and an increase in various oxidative stress markers in blood or urine