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The small molecule inhibitors or gene silencing of GLS1 expression has shown antitumor activity in a variety of cancers, including melanoma (Varghese et al., 2021), breast cancer (Gross et al., 2014), pancreatic cancer (Son et al., 2013), acute myeloid leukemia (Yamashita et al., 2021)

In the following review, we summarize available research for a correlation between FM and nutrition, and try to propose a new approach of neuronutrition management [11] in integrative programs of FM treatment