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Methylcobalamin should not be used in patients with early hereditary optic nerve atrophy (Lebers disease)

doi: 10.3389/fendo.2023.1118691 104 LwinSTOlechnowiczSWZFowlerJAEdwardsCM

[7] The dosage is adjusted based on your response to the drug, with the goal being to provide the desired benefits with the lowest effective dose possible

This means even subcutaneous abdominal injections can support healing at distant injury sites, though local injection produces more concentrated effects