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Due to their enrichment in polyunsaturated phospholipids, peroxisomal membranes are highly vulnerable to 4-HNE-induced oxidative damage, which inactivates membrane-associated proteins such as PMP70 and PEX5 and disrupts membrane integrity, giving rise to leaky peroxisomes. The uncontrolled release of ROS and matrix proteins into the cytosol intensifies oxidative stress and, through damaged mitochondriaperoxisome contact sites, impairs fatty acid trafficking and metabolic coordination, thereby aggravating lipotoxic injury in DCM

Following dosage recommendations did not show serious adverse side effects when taken for less than 12 months, but included stomach upset, breath and urine odor, and seizures in some cases

Studiu 3: Efectele L-Carnitinei asupra Metabolismului

10.1016/j.freeradbiomed.2011.03.027 Free Radic