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Bipolar disorder: trimodal age-at-onset distribution

Given its significant role in brain health and neurotransmitter signalling, low levels of B12 can affect mood regulation, contributing to feelings of sadness or lack of motivation

Depletion of plasma membrane-associated phosphoinositides mimics inhibition of TRPM7 channels by cytosolic Mg 2+ , spermine, and pH

[12] Contemporary reporting described the death as a myocardial infarction occurring in a participant who had received the eleventh weekly dose, and the trials attending physician considered the most likely explanation to be pre-existing asymptomatic coronary artery disease rather than the study drug