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2 For instance, non-recommended dose-reduced DOAC therapy was reported in 23.2% (2,423/10,426) of patients with AFib in the GARFIELD-AF registry.23 In the RIETE registry, among 4,716 patients receiving DOACs for acute VTE, 475 (10.1%) received a lower-than-recommended dose for acute treatment

However, although combined reverse administration may mitigate the side effects of low E 2 , long-term safety data remain limited [Citation165], and as a novel drug, it may face higher cost issues [Citation166]

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Discussion Liver regeneration is characterized by a precise temporal pattern of events that regulate the entry into and progression through the cell cycle, including the progression beyond the mitogen-dependent restriction point in late G1 phase, the G1/S transition and mitosis