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7 December 2020

Pirfenidone (by inhibiting TGF-1 activity) prevents the downregulation of Nrf2 and HO-1 and upregulation of Bach1 [130]

Studies suggest that combining these three peptides engages distinct but converging pathways: GHK-Cu through copper-dependent gene regulation, BPC-157 through vascular and growth factor signaling, and TB-500 through cytoskeletal and extracellular matrix dynamics