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To go through IGFBP-3 roles/effects in depth the review by Ohlsson C et al

The gonadotrophic actions of GH may potentiate testicular steroidogenesis by promoting testicular LH sensitivity and enhancing Leydig cell proliferation and development, as GH-R knockout mice may be scarce in Leydig cells and LH receptors [39]

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This dual-receptor activity partly explains the peptide broad pharmacological profile that extends well beyond simple GH secretion into cardioprotection , cytoprotection, and tissue repair