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By improving mitochondrial function, MOTS-C plays a role in optimizing energy production, reducing oxidative stress, and protecting against metabolic diseases like obesity, type 2 diabetes, and age-related metabolic decline

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Mitochondrial RNA levels of TB- 500 have been shown to increase following muscle injury, helping to regenerate muscle fibers and address inflammation in the injured location

Animal studies provide compelling evidence for transgenerational inheritance of reproductive dysfunction through epigenetic mechanisms, though human evidence remains limited