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Although the number of published studies is still limited, the integration of patient derived primary cells and organoids into OoC systems is emerging as a powerful approach to advance personalized therapy design and mechanistic disease investigation (145)

doi:10.1093/biolre/ioy208

Then, we will review the most likely candidates for conveying changes in the cellular NADPH status from the mitochondria and cytosol to the ER lumen, and we will highlight ER functions that are likely to be particularly sensitive to such changes