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Peptides at the blood brain barrier: Knowing me knowing you

Studies have shown that the Pi starvation response system in Mtb, orchestrated by the two-component system, comprising sensor histidine kinase SenX 3 and transcriptional response regulator RegX 3 , are required for full virulence in animal models of TB and are essential for Mtb growth within human macrophages in vitro [8, 1214]