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Description

This reagent is a prosubstrate that releases luciferin when it is cleaved by activated caspase-3/7

TBI-induced increases in reactive oxygen species (ROS) and reactive nitrogen species can generate hydroxyl radicals (OH) and peroxynitrite (ONOO-)

Mitochondria are essential oxygen-consuming organelles in the synthesis of ATP in skin cells, where oxygen undergoes electron transfer processes to produce ROS ( 2 ) in the skin, which induces high cytotoxicity (Figure 1) ( FIGURE 1 ROS homeostasis is critical for cell survival and protection against cell damage during signal transduction

The L chain , lacking enzymatic activity, promotes iron nucleation and long-term storage and is predominant in iron storage organs like the liver and spleen