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Tubular epithelial cellderived intracellular HMGB1 has been shown to sensitize regenerating tubular cells to oxidative stress, thereby impairing tissue repair and promoting fibrosis

Accordingly, ticks utilize various antioxidant molecules like superoxide dismutase (SOD) [25], catalase (CAT) [23, 28], glutathione peroxidase (GPx) [24] and glutathione S-transferases (GSTs) to overcome oxidative stress [21]

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The 2025 IV pilot measured cardiac, hepatic, renal, thyroid, and glucose biomarkers and reported no abnormalities (Lee et al., 2025), which gives a sense of what those investigators considered worth checking