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Molecular & Cellular Oncology, 1 (3), e963452

Targeting necroptosis pathways in NAFLD/NASH Targeting the execution process of necroptosis The recognition of necroptosis as a unique PCD mechanism has led to substantial evidence linking it to NAFLD pathogenesis and its transition to NASH and HCC

These findings were further validated in intestinal cell lines derived from rats and humans, as well as mouse and human intestinal organoids

Future studies will focus on comprehensive toxicology, long-term dosing regimens, and scaling up the manufacturing process to meet Good Manufacturing Practice (GMP) standards, which are critical steps toward human trials