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Zhang H, Wang M, He Y, Deng T, Liu R, Wang W, et al

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Development and applications of analogs of LRF and somatostatin

This review delineates the multidimensional mechanisms compromising Treg fitness, highlighting the loss of FoxP3 stability, aberrant expression of immune checkpoints (e.g., TIGIT and PD-1), and the skewing of the Th17/Treg axis as critical intrinsic drivers