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In the CNS, CCL11 has been implicated in age-associated cognitive decline, psychiatric disorders, multiple sclerosis (MS), and Alzheimers disease (AD) (reviewed in: 27 )

It can occur anywhere on the body and may be caused by various factors, including skin disorders, systemic diseases, and certain medications

All experiments were carried out in accordance with the Guide for the Care and Use of Laboratory Animals and with approval from the Institutional Animal Care and Use Committee at the University of Texas Medical Branch