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Consequently, this presents a promising opportunity for intervention in the progression of TNC-mediated tumors and evasion of the immune system (122)

Whereas GH insensitivity, both in humans and in transgenic mice, have only mild retardation of growth at birth as previously stated[3135], IGF-I deficiency in gestational state reveals serious postnatal growth retardation, as has been reported both in humans and in transgenic animal models of IGF-I deletion[3640]