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His transient symptoms and normal inter-episode laboratory findings point to a skeletal muscle channelopathy that alters resting membrane potentials during specific metabolic shifts, most commonly affecting the serum concentration of potassium

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The hydrophobicity of the phenylalanine cluster in crevasse, along with the ability of fatty acids longer than octanoic acid (C8:0), such as lauric acid (C12:0) and palmitic acid (C16:0), to activate the ghrelin receptor, initially led to the hypothesis that the fatty acid chain of ghrelin extends through this crevasse into the cell membrane (Matsumoto et al., 2001)