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This is probably, due to diverse mechanisms such as differences in the thiol content, NTR-I downregulation (Wilkinson et al., 2008), or deletion of copies of the gene encoding prostaglandin F2 synthase (referred as old yellow enzyme) that is involved in activating the anti-parasite drugs (Murta et al., 2006)

Numerous combination preventives have been used, especially combinations of nonmigraine mechanismspecific agents

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