igf-1 lr3 half life pharmacokinetics Endocrine and cellular physiology and pathology of the insulin-like growth factor acid-labile subunit Over-stimulation of insulin/IGF-1 signaling by

The exhaustion of hepatic GSH was also observed in diosbulbin B treated animals (Figure 2)

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Abbreviations ABC: ATP-binding cassette ADM: Adrenomedullin ADC: Antibodydrug conjugate APC: Antigen presenting cell CAF: Cancer-associated fibroblast CBP: Carboplatin CSC: Cancer stem cell DDR: DNA damage response DFS: Disease-free survival DTP: Drug-tolerant persister ECM: Extracellular matrix EMT: Epithelialmesenchymal transition EOC: Epithelial ovarian cancer FTE: Fallopian tube epithelium GSH: Glutathione GST: Glutathione-S-transferase HGSOC: High-grade serous ovarian cancer HRR: Homologous recombination repair IMC: Imaging mass cytometry MC: Mesothelial cell MMR: Mismatch repair MT: Metallothionein NER: Nucleotide excision repair OXPHOS: Oxidative phosphorylation PARP: Poly(ADP-ribose) polymerase PDO: Patient-derived organoid PFS: Progression-free survival PUFA: Polyunsaturated fatty acid scRNA-seq: Single-cell RNA sequencing TAM: Tumor-associated macrophage TEC: Tumor endothelial cell TME: Tumor microenvironment TSP: Tumorstroma proportion References Matulonis UA, Sood AK, Fallowfield L, Howitt BE, Sehouli J, Karlan BY

Risks and regulatory concerns exist