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This isn't speculative: radioligand binding assays conducted on human tissue samples show MC4R availability drops by approximately 35% during morning hours (6 AM12 PM) compared to evening baselines

doi: 10.1016/j.gendis.2024.101254

More research in animal and human trials, however, is needed to elucidate the relevant mechanisms of action

6.1.2.2 Primary efficacy results Clinical results demonstrated that compared to placebo, once-daily 10 mg or 25 mg brensocatib significantly extended time to first acute exacerbation