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Genetic ablation of glutathione synthesis in Tregs leads to severe multi-organ inflammation, demonstrating glutathione's critical role in immune homeostasis
The most commonly associated drugs are antibiotics (ampicillin, penicillin, cephalosporins), the sulphonamides, isoniazid, phenytoin and carbamazepine, NSAID, gold, thiazides and allopurinol Photosensitive eruptions (figure 5) Refer to the chapter Photodermatoses: drug / chemical-induced Bullous (blistering) drug reactions (figures 6-8) Can present in a number of ways: Fixed drug eruption SJS / TEN - refer to the related chapter Drug rashes - severe Immunobullous reactions - very uncommon Immunobullous reactions include: Pemphigus - penicillamine, captopril, piroxicam and rifampicin Pemphigoid - psoralens, furosemide, clonidine, ibuprofen and the sulfa drugs Linear IgA - vancomycin Pseudoporphyria - refer to the chapter Pseudoporphyria
These complications may reflect deteriorating baseline health, immune dysregulation, suboptimal therapeutic responses, or the cumulative burden of repeated invasive procedures
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