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Indeed, the depletion of NMNAT2 has been shown to reduce mitochondrial NAD + concentrations in HEK293 and HeLa cells, whereas NMNAT3 depletion does not alter mitochondrial NAD + levels in HeLa cells [101]

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More generally, the humoral immune responses of humans and NHPs to LASV-GPC can differ from responses in mice, which is due at least in part to the numerically smaller lymphocyte repertoire of the latter

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