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Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis

Trials such as MA.1R have shown that extending AIs therapy beyond 5 years significantly decreases recurrence, particularly in high-risk patients, such as those with lymph node involvement 49

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25 The committed step of shikonin and alkannin biosynthesis begins with the addition of GPP to 4HBA by a GPP:4HBA 3-geranyltransferase ( p -hydroxybenzoate: g eranyl t ransferase, PGT