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Acts as a macrophage DAMP molecule like MSU crystals to promote hyperuricemia and its complications ( via NLRP3 inflammasomes in macrophages ( UA activates phagocytosis by macrophages MSU crystals promote phagocytosis by macrophages

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Calibration of prediction models was evaluated by joint hypothesis testing of the intercept (null=0) and slope (null=1) at 6, 12, 24, and 36 mo, with p 70 years of age

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Compounding these issues, the adverse side-effects of current drugs are associated with frequent medication changes and high rates of non-adherence to treatment [10]

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doi: 10.1002/14651858.CD003373

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