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Similarly, a high-protein diet exhibits oxidative stress

Hum Reprod Update 18:525535 Morita Y, Perez GI, Paris F, Miranda SR, Ehleiter D, Haimovitz-Friedman A, Fuks Z, Xie Z, Reed JC, Schuchman EH et al (2000) Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy

Further, cysteine dioxygenase is downregulated, which appears to account for the increment in the cysteine availability for GSH synthesis in the rats supplemented with betaine [57]